Polymer University

This is a series of videos covering polymers: What they are, what they can do, and how they are being used in medical, drug delivery, and cancer research.

Polymer 101: What is a Polymer?

 

Polymer 102: Biodegradation

Introduction to polyester degradation, chemistry and rate-controlling factors.

 

Polymer 103: Micelles

Introduction to hydrophobicity, hydrophilicity, interfacial tension, and micelle formation.

 

Polymer 104: Microparticles and Nanoparticles

Introduction to applying polymer medicinal-delivery systems as microparticles and nanoparticles for controlled release.

 

Polymer 105: Thermogels

Educational video on biodegradable thermogelling polymers with focus on PLGA-PEG-PLGA block copolymer.

 

Polymer 106: Drug Delivery

Drug delivery technology and applications including intestinal uptake, targeted nanoparticle therapy, and crossing the blood-brain-barrier explained through a humorous encounter with TSA.

 

Polymer University 107: Unboxing AK149

Tech video featuring methoxy poly(ethylene glycol)-b-poly(DL)lactide copolymer and its use in formulating nanoparticles for poorly soluble drug delivery. Humorously presented in the format of a classic 'unboxing video.'

 

White Papers

Paper	Catalog Link
AFM for measuring PLGA microparticles	AP041—Poly(lactide-co-glycolide) LG 50:50 acid endcap (Mn 10,000-15,000 Da)
AI147 photocrosslinking	AI147—Stearate-modified methylcellulose acrylate
Autoclave Sterilization of PLGA-PEG-PLGA triblock	AK097—Poly(lactide-co-glycolide)-b-Poly(ethylene glycol)-b-Poly(lactide-co-glycolide) (Mw ~1700-1500-1700 Da) LA:GA 15:1
Biocompatibility review of PLGA-PEG	VP001—Poly(lactide-co-glycolide-co-graft-poly(ethylene glycol)) 65:35 LA:GA, Mn 1500 - 3500, molar PEG content: 40 - 60% VP002—Poly(lactide-co-glycolide-co-graft-poly(ethylene glycol)) 75:25 LA:GA, Mn 1500 - 3500, molar PEG content: 40 - 60% VP003—Poly(lactide-co-glycolide-co-graft-poly(ethylene glycol)) 85:15 LA:GA, Mn 1500 - 3500, molar PEG content: 40 - 60%
Blog video: strength and elasticity	AP015—Poly(L-lactide-co-caprolactone) LA:CL 50:50 (Mn 75,000-85,000 Da) L
Blog video: Thermogel Injectability	AK036—Methoxy poly(ethylene glycol)-b-poly(caprolactone) (Mw ~750:2,500 Da)
Comparison of GPC-method effects on measured Molecular weight	PLA-100L-H—Poly(D,L-lactide) decanol ester endcap high molecular weight (50 mg/vial) PLA-100L-M—Poly(D,L-lactide) decanol ester endcap medium molecular weight (50 mg/vial) PLA-100L-S—Poly(D,L-lactide) decanol ester endcap low molecular weight (50 mg/vial) PLGA-50L-H—Poly(lactide-co-glycolide) LG 50:50 acid endcap high molecular weight (50 mg/vial) PLGA-50L-H-E—Poly(lactide-co-glycolide) 50:50 LA:GA, high molecular weight (ester endcap) (50 mg/vial) PLGA-50L-M—Poly(lactide-co-glycolide) LG 50:50 decanol ester endcap medium molecular weight (50 mg/vial) PLGA-50L-S—Poly(lactide-co-glycolide) LG 50:50 decanol ester endcap low molecular weight (50 mg/vial) PLGA-75L-H—Poly(lactide-co-glycolide) decanol ester endcap high molecular weight (50 mg/vial) PLGA-75L-M—Poly(lactide-co-glycolide) decanol ester endcap medium molecular weight (50 mg/vial) PLGA-75L-S—Poly(lactide-co-glycolide) decanol ester endcap low molecular weight (50 mg/vial)
Degradation Rates of PLGA, PLA, PLCL polymers	AP081—Poly(lactide-co-glycolide) LG 50:50 acid endcap (Mn: 5,000 - 10,000 Da) AP086—Poly(D,L-lactide) ester endcap (Mn 15,000-25,000 Da) AP089—Poly(lactide-co-glycolide) acid endcap (50:50 LA:GA, Mn: 75,000-85,000 Da) AP091—Poly(lactide-co-glycolide) acid endcap (75:25 LA:GA, Mn: 15,000-25,000 Da) AP120—Poly(lactide-co-glycolide) LG 95:5 (Mn 10,000 - 15,000 Da) acid endcap AP136—Poly(lactide-co-glycolide) LG 75:25 (Mn 100,000 - 200,000 Da) acid endcap DL AP178—Poly(DL-Lactic-co-caprolactone) copolymer LA:CL 70:30 (Mn 15,000 - 25,000 Da) acid endcap DL AP190—Poly(lactide-co-glycolide) LG 75:25 (Mn 15,000 - 25,000 Da) ester endcap DL
Electrical Circuitry from NuPlon	AN001—NuPlon Resin type M317 Heat-curable resin for generation of thermoset polymer (150g bottle, patent pending)
PLGA Standards Users Guide	PLA-100L-H—Poly(D,L-lactide) decanol ester endcap high molecular weight (50 mg/vial) PLA-100L-M—Poly(D,L-lactide) decanol ester endcap medium molecular weight (50 mg/vial) PLA-100L-S—Poly(D,L-lactide) decanol ester endcap low molecular weight (50 mg/vial) PLGA-50L-H—Poly(lactide-co-glycolide) LG 50:50 acid endcap high molecular weight (50 mg/vial) PLGA-50L-M—Poly(lactide-co-glycolide) LG 50:50 decanol ester endcap medium molecular weight (50 mg/vial) PLGA-50L-S—Poly(lactide-co-glycolide) LG 50:50 decanol ester endcap low molecular weight (50 mg/vial) PLGA-75L-H—Poly(lactide-co-glycolide) decanol ester endcap high molecular weight (50 mg/vial) PLGA-75L-M—Poly(lactide-co-glycolide) decanol ester endcap medium molecular weight (50 mg/vial) PLGA-75L-S—Poly(lactide-co-glycolide) decanol ester endcap low molecular weight (50 mg/vial)
Research: Microfluidic Platform for Combinatorial Synthesis and Optimization of Targeted Nanoparticles for Cancer Therapy	AK010—Methoxy poly(ethylene glycol)-b-poly(lactide-co-glycolide) (Mw ~5,000:10,000 Da) LA:GA 50:50
Storage stability of PLCL-PEG-PLCL thermogel as aqueous solution	AK109—Poly(lactide-co-caprolactone)-b-Poly(ethylene glycol)-b-Poly(lactide-co-caprolactone) (Mw ~1700:1500:1700 Da) CL:LA 60:40
Testing effects of additives on thermogel dissolution.	AK109—Poly(lactide-co-caprolactone)-b-Poly(ethylene glycol)-b-Poly(lactide-co-caprolactone) (Mw ~1700:1500:1700 Da) CL:LA 60:40
Using Dye/Colorants with NuPlon	AN001—NuPlon Resin type M317 Heat-curable resin for generation of thermoset polymer (150g bottle, patent pending)
UV-Vis absorption of PEG-PLA/PEG-PLGA polymers	AK009—Methoxy poly(ethylene glycol)-b-poly(D,L-lactide) (Mw ~2,000:2,200 Da) AK030—Methoxy poly(ethylene glycol)-b-poly(lactide-co-glycolide) (Mw ~5,000:4,000 Da) LA:GA 50:50
White Paper: Passive dissolution of Coumarin-6 into water by PolyVivo	AK009—Methoxy poly(ethylene glycol)-b-poly(D,L-lactide) (Mw ~2,000:2,200 Da) AK012—Poly(lactide-co-glycolide)-b-poly(ethylene glycol)-b-poly(lactide-co-glycolide) (Mw ~1,000:1,000:1,000 Da) LA:GA 50:50 AK019—Poly(lactide-co-glycolide)-b-poly(ethylene glycol)-b-poly(lactide-co-glycolide) (Mw ~1,500:1,500:1,500 Da) LA:GA 50:50 AK023—Methoxy poly(ethylene glycol)-b-poly(lactide-co-glycolide) (Mw ~2,000:1,500 Da) LA:GA 50:50 AK024—Poly(lactide-co-glycolide)-b-poly(ethylene glycol)-b-poly(lactide-co-glycolide) (Mw ~1,100:1,000:1,100 Da) LA:GA 75:25 AK030—Methoxy poly(ethylene glycol)-b-poly(lactide-co-glycolide) (Mw ~5,000:4,000 Da) LA:GA 50:50 AK035—Poly(caprolactone)-b-poly(ethylene glycol)-b-poly(caprolactone) (Mw ~1,000:1,000:1,000 Da) AK036—Methoxy poly(ethylene glycol)-b-poly(caprolactone) (Mw ~750:2,500 Da) AK046—Poly(D,L-lactide)-b-poly(ethylene glycol)-b-poly(D,L-lactide) (Mw ~1,000:1,000:1,000 Da) AK047—Methoxy poly(ethylene glycol)-b-poly(L-lactide) (Mw ~5,000:1,000 Da) AK048—Methoxy poly(ethylene glycol)-b-poly(L-lactide) (Mw ~5,000:500 Da) AO014—Poly(N-isopropylacrylamide-co-acrylic acid) 95:5 NIPAM:AA AO016—Poly(N-isopropylacrylamide-co-acrylamide) 50:50 NIPAM:AM AO017—Poly(N-isopropylacrylamide-co-methoxy poly(ethylene glycol) methacrylate) 95:5 NIPAM:mPEG (Mn 475 Da) AO018—Poly(vinylcaprolactam-co-methoxy poly(ethylene glycol) methacrylate) 95:5 VCL:mPEG AO019—Poly(dimethylaminoethyl methacrylate-co-methoxy poly(ethylene glycol)) 95:5 DMAEMA:mPEG AO020—Poly(Poloxamer 407)-co-hexamethylene-diisocyanate copolymer methoxy poly(ethylene glycol) 10:1 PF:mPEG nominal 10 poloxamer chains/mPEG endcap (5,000 Da) AO021—Poly(N-isopropylacrylamide-co-acrylamide) 75:25 NIPAM:AM AO023—Poly(N-isopropylacrylamide-co-acrylamide) 95:5 NIPAM:AM AO026—Poly(Poloxamer 407)-methylene-diphenyl-di-isocyanate linked AO031—Poly(N-vinylcaprolactam) Viscosity 20% w/v solution at 5C: 0.01 - 0.5 Pa.s
White Paper: Thermogel Mixtures impact on Rheology	AK019—Poly(lactide-co-glycolide)-b-poly(ethylene glycol)-b-poly(lactide-co-glycolide) (Mw ~1,500:1,500:1,500 Da) LA:GA 50:50
WhitePaper: AI057 viscosity in water	AI057—Poly(N-isopropylacrylamide)-N-hydroxysuccinimide endcap (Inherent viscosity (I.V.) = 0.2-0.5 dL/g in methanol at 25C)
WhitePaper: AO23 cold viscosity	AO023—Poly(N-isopropylacrylamide-co-acrylamide) 95:5 NIPAM:AM
WhitePaper: In-vivo imaging with PolyVivo AV006 (PLGA-FPI749)	AV006—Poly(lactide-co-glycolide)-FPI749 LG 50:50 FPI749 endcap Flamma Fluor near-IR conjugated (Mn 20,000-30,000 Da) (nominal 2mg/G labeling)
WhitePaper: PolyVivo AO19 pH and temperature sensitive	AO019—Poly(dimethylaminoethyl methacrylate-co-methoxy poly(ethylene glycol)) 95:5 DMAEMA:mPEG
WhitePaper: Sensitive to both pH and temperature	AO014—Poly(N-isopropylacrylamide-co-acrylic acid) 95:5 NIPAM:AA
WhitePaper: Thermal properties mPEG-PCL polymers	AK001—Methoxy poly(ethylene glycol)-b-poly(caprolactone) (Mw ~2,000:5,200 Da)
WhitePaper: Thermogel speed of mixed PolyVivo AK019 and AK012	AK012—Poly(lactide-co-glycolide)-b-poly(ethylene glycol)-b-poly(lactide-co-glycolide) (Mw ~1,000:1,000:1,000 Da) LA:GA 50:50
WhitePaper: Thermogel Users Guide	AK012—Poly(lactide-co-glycolide)-b-poly(ethylene glycol)-b-poly(lactide-co-glycolide) (Mw ~1,000:1,000:1,000 Da) LA:GA 50:50
WhitePaper: Thermogels mixed with biocomponents for 3D cell scaffold	AO025—Stearate-modified methyl cellulose Hydrophobically modified thermogel AO026—Poly(Poloxamer 407)-methylene-diphenyl-di-isocyanate linked
WhitePaper: Thermosensitive nanoparticles AO034 loaded with Coumarin-6	AO034—Poly(N-vinylcaprolactam-co-methylmethacrylate) 90:10 VCL:MMA (Inherent Viscosity (I.V.) = 0.3-0.7 dL/g in ethanol at 30C)
WhitePaper: Using AK01 to form poorly soluble drug loaded liposomes	AK001—Methoxy poly(ethylene glycol)-b-poly(caprolactone) (Mw ~2,000:5,200 Da)
WhitePaper: Viscosity and Thermal Properties (AK12)	AK012—Poly(lactide-co-glycolide)-b-poly(ethylene glycol)-b-poly(lactide-co-glycolide) (Mw ~1,000:1,000:1,000 Da) LA:GA 50:50