Akinalytics
Polymer Blog
Publications authored by Akina, Inc. employees
You can also view a searchable list of publications by other researchers that used specific PolySciTech polymers.
Qualitative/Quantitative (Q1/Q2) Sameness/Bioequivalence assay development
J. Garner, Justin Hadar, S. Skidmore, F. Jessmon, H. Park, K. Park, A. Otte, X. Xu, Y. K. Jhon, B. Qin, Y. Wang. “Scanning Analysis of Semi-solvent Vapor Impact (SAVI): Microstructural and compositional analysis of leuprolide loaded poly(lactide co glycolide) microparticles” Scientific Poster presented at 2023 annual meeting of Controlled Release Society
Garner, John, Sarah Skidmore, Justin Hadar, Haesun Park, Kinam Park, Bin Qin, Yan Wang. “Surface analysis of sequential semi-solvent vapor impact (SAVI) for studying microstructural arrangements of poly (lactide-co-glycolide) microparticles” Journal of Controlled Release 350 (2022) 600–612
J. Garner, J. Hadar, S. Skidmore, F. Jessmon, H. Park, K. Park, B. Qin, Y. K. Jhon, Y. Wang “Morphological analysis of naltrexone-poly(lactide-co-glycolide) (NTX-PLGA) microparticles: Dynamic role of naltrexone on PLGA degradation” Scientific Poster presented at 2022 annual meeting of Controlled Release Society
J. Garner, J. Hadar, S. Skidmore, F. Jessmon, H. Park, K. Park, B. Qin, Y. K. Jhon, Y. Wang “Scanning analysis of semi-solvent impact using sequential solvent vapor (SASSI-SSV):Assay of poly(lactide-co-glycolide)-naltrexone (PLGA-NTX) microparticles” Scientific Poster presented at 2022 annual meeting of Controlled Release Society
J. Garner, J. Hadar, S. Skidmore, F. Jessmon, H. Park, K. Park, Y. K. Jhon, B. Qin, Y. Wang. “Scanning Analysis of Semi-Solvent Impact (SASSI) assays of naltrexone microparticles manufactured using different solvents” Scientific Poster presented at 2021 annual meeting of Controlled Release Society
J. Garner, J. Hadar, S. Skidmore, F. Jessmon, H. Park, K. Park, Y. K. Jhon, B. Qin, Y. Wang. “Effect of reaction temperature on PLGA properties and semi-solvent interactions.” Scientific Poster presented at 2021 annual meeting of Controlled Release Society
J. Garner, J. Hadar, S. Skidmore, F. Jessmon, H. Park, K. Park, Y. K. Jhon, B. Qin, Y. Wang. “Effect of Solvent Isomeric Structures on the Dissolution of PLGAs with Different Lactide:Glycolide (L:G) Ratios” Scientific Poster presented at 2021 annual meeting of Controlled Release Society
Garner, John, Sarah Skidmore, Justin Hadar, Haesun Park, Kinam Park, Young Kuk Jhon, Bin Qin, and Yan Wang. “Analysis of semi-solvent effects for PLGA polymers.” International Journal of Pharmaceutics (2021): 120627.
Park, Kinam, Andrew Otte, Farrokh Sharifi, John Garner, Sarah Skidmore, Haesun Park, Young Kuk Jhon, Bin Qin, and Yan Wang. “Potential Roles of the Glass Transition Temperature of PLGA Microparticles in Drug Release Kinetics.” Molecular Pharmaceutics (2020).
Park, Kinam, Andrew Otte, Farrokh Sharifi, John Garner, Sarah Skidmore, Haesun Park, Young Kuk Jhon, Bin Qin, and Yan Wang. “Formulation composition, manufacturing process, and characterization of poly (lactide-co-glycolide) microparticles.” Journal of Controlled Release (2020).
J. Garner, J. Hadar, S. Skidmore, F. Jessmon, H. Park, K. Park, Y. Wang, B. Qin, Y. Jhon. “Effect of Solvent Isomeric Structures on the Dissolution of PLGAs with Different Lactide:Glycolide (L:G) Ratios” Scientific Poster presented at 2020 annual meeting of Controlled Release Society
J. Garner, J. Hadar, S. Skidmore, F. Jessmon, H. Park, K. Park, Y. Wang, B. Qin, Y. Jhon. "Use of Optical-Laser-Scanning (OLS) Microscope to Assay Microparticle Morphological Changes" Scientific Poster presented at 2020 annual meeting of Controlled Release Society
John Garner, “Poly(lactide-co-glycolide) Semi-Solvent Separation: A Tale of Many Polymers in One” Presented as part of "Equivalence of Complex Long Acting Drugs" at 2020 annual meeting of Controlled Release Society.
Justin Hadar, Sarah Skidmore, John Garner, Haesun Park, Kinam Park, Yan Wang, Bin Qin, Xiaohui (Jeff) Jiang, Darby Kozak “Method matters: Development of characterization techniques for branched and glucose-poly(lactide-co-glycolide) polymers”, Journal of Controlled Release Volume 320, 10 April 2020, Pages 484-494.
John Garner - Slide Presentation “Complex Sameness: Tests to Determine Properties for PLGA Excipients in Long-Acting Formulations” presented as part of Technology Forum “Implants and Depots – How To meet Challenges in Polymeric Controlled Release with Bioresorbable and Biodurable Materials” at 2019 annual meeting of Controlled Release Society
J. Hadar, J. Garner, S. Skidmore, H. Park, K. Park, B. Qin, X. Jiang, Y. Wang. “Analysis of the branch units of glucose-poly(lactide-co-glycolide) in Sandostatin® LAR formulation” Scientific Poster presented at 2019 annual meeting of Controlled Release Society
J. Hadar, J. Garner, S. Skidmore, H. Park, K. Park, B. Qin, X. Jiang, Y. Wang. “Compositional analysis of glucose-poly(lactide-co-glycolide) in Sandostatin® LAR formulation” Scientific Poster presented at 2019 annual meeting of Controlled Release Society
J. Garner, J. Hadar, S. Skidmore, H. Park, K. Park, B. Qin, X. Jiang, Y. Wang. “Separation and analysis of poly(lactide-co-glycolide) in Trelstar® 22.5 mg formulation” Scientific Poster presented at 2019 annual meeting of Controlled Release Society
J. Garner, J. Hadar, S. Skidmore, H. Park, K. Park, B. Qin, X. Jiang, Y. Wang. “Effect of solvents and their isomers on dissolution of PLGAs with different lactide:glycolide (L:G) ratios” Scientific Poster presented at 2019 annual meeting of Controlled Release Society
Park, Kinam, Sarah Skidmore, Justin Hadar, John Garner, Haesun Park, Andrew Otte, Bong Kwan Soh et al. “Injectable, long-acting PLGA formulations: Analyzing PLGA and understanding microparticle formation.” Journal of Controlled Release (2019).
Hadar, Justin, Sarah Skidmore, John Garner, Haesun Park, Kinam Park, Yan Wang, Bin Qin, and Xiaohui Jiang. “Characterization of branched poly (lactide-co-glycolide) polymers used in injectable, long-acting formulations.” Journal of Controlled Release (2019).
Skidmore, Sarah, Justin Hadar, John Garner, Haesun Park, Kinam Park, Yan Wang, and Xiaohui Jiang. “Complex sameness: Separation of mixed poly (lactide-co-glycolide) s based on the lactide: glycolide ratio.” Journal of Controlled Release (2019).
J. Hadar, J. Garner, S. Skidmore, H. Park, K. Park, Y. K. Jhon, Y. Wang. “Correlation Analysis of Refractive Index (dn/dc) for PLGAs with Different Ratios of Lactide to Glycolide” Scientific Poster presented at 2018 annual meeting of Controlled Release Society
J. Hadar, J. Garner, S. Skidmore, H. Park, K. Park, D. Kozak, Y. Wang. “Solvent-dependent PLGA solubility for separation of PLGAs with different L:G ratios” Scientific Poster presented at 2018 annual meeting of Controlled Release Society
J. Garner, S. Skidmore, K. Park, H. Park, S. Choi, Y. Wang. “Assay of Polymeric Sustained Delivery Systems for Carrier Properties” presented at 2016 American Association of Pharmaceutical Sciences (AAPS) annual meeting November 13-17th, Denver Colorado
J. Garner , S. Skidmore, H. Park, K. Park, S. Choi, Y. Wang. “Assay of Clinical Product Long-Term Delivery Systems for PLGA Properties” presented at 2016 Controlled Release Society (CRS) annual meeting July 17-20, Seattle Washington
Garner, John, Sarah Skidmore, Haesun Park, Kinam Park, Stephanie Choi, and Yan Wang. “Beyond Q1/Q2: The impact of manufacturing conditions and test methods on drug release from PLGA-based microparticle depot formulations.” Journal of Pharmaceutical Sciences (2017).
J. Garner, S. Skidmore, J. Hadar, K. Park, H. Park, S. Choi, Y. Wang Assay of PLGA Types in Microparticle Depo Formulations Poster Presentation at FDA public workshop “Demonstrating Equivalence of Generic Complex Drug Substances and Formulations” October 6, 2017
Justin Hadar, J. Garner, S. Skidmore, K. Park, H. Park, S. Choi, Y. Wang The Effect of Lactide:Glycolide Ratio on PLGA Solubility in Selective Solvents Poster Presentation at FDA public workshop “Demonstrating Equivalence of Generic Complex Drug Substances and Formulations” October 6, 2017
S. Skidmore, J. Garner, K. Park, H. Park, S. Choi, Y. Wang The impact of in vitro test methods on drug release from PLGA microparticles Poster Presentation at FDA public workshop “Demonstrating Equivalence of Generic Complex Drug Substances and Formulations” October 6, 2017
Garner, John, Sarah Skidmore, Haesun Park, Kinam Park, Stephanie Choi, and Yan Wang. “A protocol for assay of poly (lactide-co-glycolide) in clinical products.” International journal of pharmaceutics 495, no. 1 (2015): 87-92.
Restiex® Tissue Expander
Garner, John, Darrell D. Davidson, Daria Barwinska, George J. Eckert, Sunil S. Tholpady, Kinam Park, and Clark T. Barco. “Reshapeable hydrogel tissue expander for ridge augmentation: Results of a series of successive insertions at the same intraoral site.” Journal of Periodontology (2019).
Garner, John, Darrel Davidson, George J. Eckert, Clark T. Barco, Haesun Park, and Kinam Park. “Reshapable polymeric hydrogel for controlled soft-tissue expansion: in vitro and in vivo evaluation.” Journal of Controlled Release 262 (2017): 201-211.
Kun Young Yuk, Ye-Tae Kim, Su Jin Im, John Garner, Yourong Fu, Kinam Park, Jeong-Sook Park, Kang Moo Huh “Preparation and Characterization of Biodegradable Hydrogels for Tissue Expander Application” Polymer(Korea), Vol.34, No.3, 253-260, 2010.
Book Chapter: T.H. Tran, J. Garner, Y. Fu, K. Park, K.M. Huh “Biodegradable Elastic Hydrogels for Tissue Expander Application” in Handbook of Biodegradable Polymers, Wiley-VCH Verlag GmbH & Co. KGaA, pp. 217-236
Daria Barwinska, PhD, John Garner, BS, Darrell D. Davidson, MD, PhD, Todd G. Cook, AAS, George J. Eckert, MAS, Sunil S. Tholpady, MD, PhD, Keith L. March, MD, PhD, Kinam Park, PhD, Clark T. Barco, DDS, MS. “Mucosal Perfusion Preservation by a Novel Shapeable Tissue Expander for Oral Reconstruction.” PRS Global Open (2017)
Huh, Kang, You Choi, Jae Park, and Kinam Park. “Readily shapeable xerogels having controllably delayed swelling properties.” U.S. Patent Application 11/495,153, filed February 8, 2007.
Park, Kinam, Clark Tobias Barco, Haesun Park, Yourong Fu, and John Solomon Garner. "Novel hydrogel tissue expanders." U.S. Patent Application 15/304,495, filed February 9, 2017.
Hydrogel Template Microparticles
Acharya, Ghanashyam, Crystal S. Shin, Matthew McDermott, Himanshu Mishra, Haesun Park, Ick Chan Kwon, and Kinam Park. “The hydrogel template method for fabrication of homogeneous nano/microparticles.”Journal of Controlled Release 141, no. 3 (2010): 314-319.
Acharya, Ghanashyam, Matthew McDermott, Soo Jung Shin, Haesun Park, and Kinam Park. “Hydrogel templates for the fabrication of homogeneous polymer microparticles.” Biomedical Nanotechnology: Methods and Protocols(2011): 179-185.
Acharya, Ghanashyam, Crystal S. Shin, Kumar Vedantham, Matthew McDermott, Thomas Rish, Keith Hansen, Yourong Fu, and Kinam Park. “A study of drug release from homogeneous PLGA microstructures.” Journal of Controlled Release 146, no. 2 (2010): 201-206.
He, Yuanzu, and Kinam Park. “Effects of the Microparticle Shape on Cellular Uptake.” Molecular pharmaceutics (2016).
Park, Kinam, Ghanashyam Acharya, and Haesun Park. "Sol-gel phase-reversible hydrogel templates and uses thereof." U.S. Patent 8,951,567, issued February 10, 2015.
Park, Kinam, and Christopher A. Rhodes. "Biodegradable Microcapsules Containing Filling Material." U.S. Patent Application 15/832,368, filed July 5, 2018.
Park, Kinam, Yeonhee Yun, Sarah Michelle Skidmore, Byung Kook Lee, and John Solomon Garner. "Biodegradable polymer formulations for extended efficacy of botulinum toxin." U.S. Patent Application 15/684,134, filed March 1, 2018.
Park, Kinam, Sarah Michelle Skidmore, Larry Fultz, Yeonhee Yun, and Byung Kook Lee. "Device for large-scale microparticle production and method of using the same." U.S. Patent 9,855,218, issued January 2, 2018.
Cancer Modeling (3DCellMaker)
Chhetri, Apekshya, Shirisha Chittiboyina, Farzaneh Atrian, Yunfeng Bai, Davide A. Delisi, Rahim Rahimi, John Garner, Yuri Efremov, Kinam Park, Rabih Talhouk and Sophie A. Lelièvre “Cell Culture and Coculture for Oncological Research in Appropriate Microenvironments.” Current Protocols in Chemical Biology (2019): e65.
J. Hadar, J. Garner, S. Skidmore, H. Park, K. Park, B. Han, F. Atrian, S.A. Lelièvre. “3DCellMakers: Thermogelling Polymers for 3D Cell Culture” Poster presented at CRS 2016
Garner, John Solomon, Sarah Michelle Skidmore, Justin Charles Hadar, H. A. N. Burnsoo, and Kinam Park. "Polymers for Inducing 3D Spheroid Formation of Biological Cells." U.S. Patent Application 15/533,027, filed December 21, 2017.
Hydrogels (Aquagel)
Yui, Nobuhiko, Randall J. Mrsny, and Kinam Park, eds. Reflexive polymers and hydrogels: understanding and designing fast responsive polymeric systems CRC press, 2004.
Quick-dissolve tablets (Frosta)
Fu, Yourong, Seong Hoon Jeong, and Kinam Park. “Fast-melting tablets based on highly plastic granules.” Journal of controlled release 109, no. 1 (2005): 203-210.
Jeong, Seong Hoon, Yuuki Takaishi, Yourong Fu, and Kinam Park. “Material properties for making fast dissolving tablets by a compression method.”Journal of Materials Chemistry 18, no. 30 (2008): 3527-3535.
Fu, Yourong, Chaul Min Pai, Sang Yeob Park, Gun Seomoon, and Kinam Park. "Highly plastic granules for making fast melting tablets." U.S. Patent 7,749,533, issued July 6, 2010.
Jeong, Seonghoon, Susumu Kimura, Yourong Fu, and Kinam Park. "Fast-melting tablets having taste-masking and sustained release properties." U.S. Patent Application 11/267,568, filed June 1, 2006.
Drug-Delivery (General)
Cho, Yong Woo, Jaehwi Lee, Sang Cheon Lee, Kang Moo Huh, and Kinam Park. “Hydrotropic agents for study of in vitro paclitaxel release from polymeric micelles.” Journal of Controlled Release 97, no. 2 (2004): 249-257.
Lee, Jaehwi, Sang Kil Lww, and Young Wook Choi. “The effect of storage conditions on the permeability of porcine buccal mucosa.” Archives of pharmacal research 25, no. 4 (2002): 546-549.
Lee, Jaehwi, Sung-Up Choi, Mi-Kyeong Yoon, and Young Wook Choi. “Kinetic characterization of swelling of liquid crystalline phases of glyceryl monooleate.” Archives of pharmacal research 26, no. 10 (2003): 880-885.
Lee, Jaehwi, and Young Wook Choi. “Enhanced ex vivo buccal transport of propranolol: Evaluation of phospholipids as permeation enhancers.” Archives of pharmacal research 26, no. 5 (2003): 421-425.
Cho, Yong Woo, Jong‐Duk Kim, and Kinam Park. “Polycation gene delivery systems: escape from endosomes to cytosol.” Journal of pharmacy and pharmacology 55, no. 6 (2003): 721-734.
Huh, Kang Moo, Yong Woo Cho, and Kinam Park. "PLGA-PEG block copolymers for drug formulations." Drug Dev Deliv3, no. 5 (2003).
Drug-Delivery (Stents)
Acharya, Ghanashyam, and Kinam Park. “Mechanisms of controlled drug release from drug-eluting stents.” Advanced drug delivery reviews 58, no. 3 (2006): 387-401.
Book Chapter: “Future Outlook For Drug Eluting Stents” K. Vedantham, S. Chaterji, J. Kitsongsermthon, K. Park, J. Garner, in: A. Lewis (Ed.), “Drug-Device Combination Products Delivery Technologies and Applications”, Woodhead Publishing Ltd, Cambridge, UK, 2010, pp. 117-153.
Hydrogels (General)
Gasek, Nathan, Heon E. Park, Juan J. Uriarte, Franziska E. Uhl, Robert A. Pouliot, Alexander Riveron, Tovah Moss, Zachary Phillips, Jessica Louie, Ishna Sharma, Benefsha Mohammed, Jacob Dearborn, Patrick C. Lee, Todd Jensen, John Garner, Christine Finck, Daniel J. Weiss “Development of Alginate and Gelatin-Based Pleural and Tracheal Sealants.” Acta Biomaterialia (2021).
Garner, John, Justin Hadar, Sarah Skidmore, Faye Jessmon, Rebecca Immel, Amie Tyler, and Kinam Park. “Narrow molecular weight margins for the thermogelling property of polyester–polyether block copolymers in aqueous solutions” J Appl Polym Sci, 48673.
Garner, John, and Kinam Park. “Chemically Modified Natural Polysaccharides to Form Gels.” In Polysaccharides, pp. 1-25. Springer International Publishing, 2014.
Garner, John, and Kinam Park. “Types and chemistry of synthetic hydrogels.” Gels Handbook: Fundamentals, Properties and Applications (In 3 Volumes) Volume 1: Fundamentals of HydrogelsVolume 2: Applications of Hydrogels in Regenerative MedicineVolume 3: Application of Hydrogels in Drug Delivery and Biosensing (2016): 17.
Korean Language Publications
http://www.cheric.org/article/833216
